Not Losing Weight on a GLP-1 or Dual-Action Medication? Here’s Why

GLP-1 receptor agonists and dual-action GLP-1/GIP therapies have changed the landscape of medical weight loss in Ireland. But what happens when you’re taking a clinically proven weight loss treatment, and the scale isn’t moving?

First: you’re not alone.

Even when appetite is reduced, weight loss still requires a consistent calorie deficit, proper nutrition, and regular movement. Here’s a breakdown of the most common reasons weight loss may stall — and what you can do to get results.

GLP-1 Medications Reduce Hunger — Not Calories

These medications work by helping you feel fuller with less food. But they don’t control:

  • What you eat
  • How much do you eat
  • How your body processes different foods

It’s still possible to consume more calories than you burn — especially with energy-dense or liquid foods — even when hunger is reduced.

Common Nutrition Mistakes
  1. You’re Eating Less Often, But Not Less Overall
  • Skipping meals may lead to larger, more calorie-dense portions later
  • Prolonged under-eating can cause intense rebound hunger
  1. High-Calorie “Healthy” Foods Add Up
  • Foods like nuts, granola, smoothies, avocado, and protein bars are healthy but calorie-dense
  • Portion sizes can quickly push you into a deficit
  1. You’re Not Tracking Your Intake
  • Research shows most people underestimate calories by 20–40%
  • Sauces, oils, drinks, and “small bites” can significantly add up
  1. You’re Drinking Calories
  • Smoothies, alcohol, protein shakes, and sugary coffees aren’t always well-regulated by appetite suppression
  • Liquid calories are absorbed quickly and may delay satiety
 Nutrition Fixes
  • Track intake for 5–7 days using apps like MyFitnessPal or Cronometer
  • Prioritise protein: eggs, chicken, tofu, fish, Greek yogurt
  • Choose fibre-rich vegetables: broccoli, leafy greens, carrots, courgette
  • Limit:
    • Ultra-processed snacks
    • Sugary drinks and alcohol
    • Takeaway and oversized restaurant meals
Exercise Mistakes That Can Stall Progress

Although GLP-1 medications can help preserve lean mass, inactivity and poor training strategies can limit results.

  1. You’re Relying on Walking Alone
  • Walking is excellent for heart health, but it may not provide sufficient muscle stimulation to alter body composition significantly.
  1. You’re Doing Cardio But Not Resistance Training
  • Without strength training, weight loss can include muscle loss, which reduces metabolic rate
  • Resistance training tells your body to retain muscle, not burn it
  1. You’re Not Moving Enough Overall
  • If you’re sedentary (e.g., desk job), you may burn only 1,500–1,800 kcal/day
  • Without movement, even a reduced appetite may not create a large enough deficit

Exercise Fixes

  • Add resistance training 2–3x/week: squats, pushups, resistance bands, or light weights
  • Aim for daily movement bursts (e.g., 10-minute walks after meals = ~100–200 kcal/day burned)
  • Use fitness trackers (Apple Watch, Fitbit, Oura) to monitor steps and activity
  • Combine aerobic + resistance training for best results
Other Key Factors
  1. You’re in the Early Phase of Treatment
  • Starting doses of GLP-1 medications are designed to minimise side effects — not trigger maximum weight loss
  • Most people see greater effects after 8–12 weeks of dose titration

What to do: Stay on schedule and trust the process. Don’t rush dose increases.

  1. You’re Over-Focused on the Scale
  • Water retention, menstrual cycle shifts, or muscle gain can temporarily mask fat loss
  • Many people lose inches before pounds

What to do:

  • Track non-scale progress (clothing fit, waist size, mood, energy)
  • Take photos every 2–4 weeks
  1. You’re Not Sleeping or Managing Stress
  • Poor sleep increases hunger hormones and cravings
  • High stress raises cortisol, which can blunt fat loss

What to do:

  • Aim for 7–9 hours of quality sleep per night
  • Build in relaxation: deep breathing, stretching, journaling, or walking
Health Checks to Consider

If weight loss continues to stall despite proper nutrition and activity, consider checking:

  • Thyroid function (TSH, T3, T4)
  • Liver and kidney markers
  • Cortisol or blood sugar levels

Speak with your doctor for tailored blood work recommendations.

What You Can Do Next
  • Log your food for 3–5 days
  • Add or reintroduce resistance training
  • Set a protein intake target: ~1.6g per kg of body weight per day
  • Cut back on ultra-processed snacks and calorie-rich drinks
  • Prioritise sleep and stress management
  • Focus on consistency, not perfection
Final Thoughts

GLP-1 medications are powerful tools, but they are not magic fixes. Think of them as supportive frameworks, not a shortcut.

By aligning your nutrition, movement, recovery, and mindset, you can unlock the full potential of your treatment and reach your goals safely and sustainably.

Small change. Big shift.

Your health, your pace, your plan. We’re just here to make it easier.

Small change. 

Big shift.

Your health, your pace, your plan. We’re just here to make it easier.