Choosing the Right Treatment for Medically Supervised Weight Loss in Ireland
In 2025, the field of medical weight loss in Ireland has evolved. Prescription-based GLP-1 therapies and dual-action weight loss injections have become game-changing options for individuals who have struggled with traditional diets or plateaued despite their efforts.
But with more than one type of treatment available, it’s essential to understand:
Which option is right for you?
This guide compares the two leading classes of weekly weight loss injections, explains how they work, and helps you identify which approach may best suit your goals.
Option 1: GLP-1 Receptor Agonists
GLP-1 receptor agonists are a class of medications that:
- Mimic the GLP-1 hormone, which helps reduce appetite and regulate blood sugar
- Slow gastric emptying to prolong feelings of fullness
- Are administered as weekly subcutaneous injections
- Require a gradual dose increase to minimise side effects
Average weight loss: ~15% of starting body weight (based on 68-week clinical trials)
Option 2: Dual-Action GLP-1/GIP Therapies
Dual-action therapies mimic two hormones: GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). This dual mechanism results in:
- Stronger appetite suppression
- Improved insulin sensitivity
- Enhanced blood sugar control
- Faster and deeper fat loss for many individuals
These therapies also use a weekly injection format, with titration from a low starting dose up to higher therapeutic levels.
Average weight loss: ~20–22% of body weight in clinical trials over 72 weeks
How Do These Options Compare?
| Feature | GLP-1 Therapy | Dual-Action Therapy |
| Mechanism | Mimics GLP-1 hormone | Mimics GLP-1 and GIP |
| Appetite Control | Strong | Very strong |
| Weight Loss (Avg) | ~15% of starting weight | ~20–22% of starting weight |
| Speed of Results | Moderate | Faster |
| Blood Sugar Benefits | Effective | More robust |
| Weekly Dosing | Yes | Yes |
| Dose Titration | Gradual | Gradual |
| Side Effects | Mostly GI-related (nausea, etc.) | Similar, sometimes stronger initially |
Clinical Study Summary
GLP-1 Only Therapy:
- 83% of participants lost ≥5% of their weight
- Half lost ≥15%
- Cardiovascular markers improved significantly
Dual-Action Therapy:
- 96% lost ≥5%
- Over 30% lost ≥25%
- Strong metabolic benefits even in individuals with insulin resistance
Who Is Eligible?
Both treatment types are suitable for adults who:
- Have a BMI ≥30, or
- Have a BMI ≥27 with a weight-related condition such as:
- High blood pressure
- PCOS
- High cholesterol
- Sleep apnea
Important:
We do not prescribe these medications for individuals with type 2 diabetes.
If you have diabetes, it is recommended that you consult your GP or specialist team, as your treatment may involve additional clinical considerations.
All treatments require a medical consultation with a licensed Irish doctor. Prescriptions are issued only if the treatment is medically appropriate.
Typical Dosing Schedules
GLP-1 Therapy (Titration Example):
| Weeks | Dose |
| 1–4 | 0.25 mg |
| 5–8 | 0.5 mg |
| 9–12 | 1.0 mg |
| 13–16 | 1.7 mg |
| 17+ | 2.4 mg |
Dual-Action Therapy (Titration Example):
| Weeks | Dose |
| 1–4 | 2.5 mg |
| 5–8 | 5.0 mg |
| 9–12 | 7.5 mg |
| 13–16 | 10 mg |
| 17+ | 12.5–15 mg |
Doses are illustrative and may vary. Your doctor will determine the appropriate titration plan.
Side Effects: What to Expect
Most side effects are digestive and tend to reduce over time.
| Symptom | GLP-1 Therapy | Dual-Action Therapy |
| Nausea | Common | Common (may be stronger at higher doses) |
| Diarrhoea | Occasional | Common |
| Constipation | Occasional | Occasional |
| Fatigue | Rare | Rare |
| Vomiting | Rare | Occasional |
| Pancreatitis Risk | Rare (monitored) | Rare (monitored) |
Which Treatment Is Right for You?
| Goal / Preference | Better Fit |
| Proven long-term safety and results | GLP-1 Therapy |
| Faster, deeper weight loss | Dual-Action Therapy |
| Gentler titration for sensitive stomachs | GLP-1 Therapy |
| Stronger metabolic or insulin impact | Dual-Action Therapy |
Your prescribing doctor will help determine the best option based on your health history, goals, and lifestyle.
FAQs
Q 1: Can I switch from one type to another?
Q 1: Yes, some patients transition if progress slows. This is done under medical supervision.
Q 2: Are these treatments reimbursed?
A 2: Currently, weight loss treatments are not typically reimbursed by Irish private insurers unless prescribed for another approved condition.
Q 3: Can I get these medications delivered?
A 3: Yes, once prescribed, you can collect from your pharmacy or opt for home delivery through a licensed Northern Irish pharmacy partner.
Q 4: Do I need to exercise?
A 4: Yes, combining these injections with strength training, walking, and a high-protein diet supports the best results.
Why Choose WeightLossInjections.ie?
- 100% Irish-registered doctors
- Fully online consultation – no video or in-person appointments required
- Access to both GLP-1 and dual-action options
- Prescriptions accepted in both ROI and NI
- Secure, discreet delivery available
- Transparent pricing with no subscriptions or hidden fees
Final Thoughts
Whether you’re seeking a slower, steady approach or a faster, deeper intervention, GLP-1-based injections are changing how weight loss is managed in Ireland.
Let our doctors guide you to the option that fits your life best, with complete clinical oversight and ongoing support.
